Article
Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations.
Archives of general psychiatry - 1 Nov 1998
Lappalainen J, Long J C, Eggert M, Ozaki N, Robin R W, Brown G L, Naukkarinen H, Virkkunen M, Linnoila M, Goldman D
Abstract excerpt
BACKGROUND: In mice, quantitative trait locus studies and behavioral evaluation of animals deleted for 5-HT1B have implicated this serotonin autoreceptor in alcohol consumption and aggressive behavior. We therefore investigated whether the 5-HT1B gene (HTR1B) is linked to alcoholism with aggressi...
Topics
- Adolescent
- Adult
- Alcoholism
- Animals
- Antisocial Personality Disorder
- Base Sequence
- Comorbidity
- Disruptive, Impulse Control, and Conduct Disorders
- Female
- Finland
- Genetic Linkage
- Genotype
- Humans
- Indians, North American
- Male
- Mice
- Molecular Sequence Data
- Pedigree