Article
Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 1996
Philip P A, Souliotis V L, Harris A L, Salisbury A, Tates A D, Mitchell K, van Delft J H, Ganesan T S, Kyrtopoulos S A
Abstract excerpt
Dacarbazine (DTIC) is a DNA-methylating drug used in the treatment of malignant melanoma. Among the DNA dducts induced by DTIC are N7-methylguanine (N7-meG) and O6-methylguanine (O6-meG). The latter adduct, in particular, may be important in the mutagenic as well as the cytotoxic activity of DTIC. Repair of O6-meG is carried out by the enzyme O6-alkylguanine-DNA-alkyltransferase (AGT) by a process which results...
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