Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absence of mutations in DNA mismatch repair genes in sporadic endometrial tumors with microsatellite instability.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 1996

Lim P C, Tester D, Cliby W, Ziesmer S C, Roche P C, Hartmann L, Thibodeau S N, Podratz K C, Jenkins R B

Abstract excerpt

DNA mismatch repair genes have been reported to play a role in the pathogenesis of hereditary nonpolyposis colorectal cancer (HNPCC). Mutations of DNA mismatch repair genes have accounted for 90% of HNPCC-related colon and endometrial tumors. These mutations have been associated with microsatelli...

Topics

Adaptor Proteins, Signal Transducing
Carrier Proteins
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
Endometrial Neoplasms
Female
Humans
Microsatellite Repeats
MutL Protein Homolog 1
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

Nuclear Proteins

Source

Identifiers

PMID: 9816148

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9816148-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of mutations in DNA mismatch repair genes in sporadic endometrial tumors with microsatellite instability.PMID 9816148Read ↗

Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.Semantic proximity Read ↗

Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers.Semantic proximity Read ↗

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial CancersSemantic proximity Read ↗

Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma.Semantic proximity Read ↗

Hereditary and somatic DNA mismatch repair gene mutations in sporadic endometrial carcinomaSemantic proximity Read ↗

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.Semantic proximity Read ↗

Usefulness of immunohistochemistry for mismatch repair protein and microsatellite instability examination in adenocarcinoma and background endometrium of sporadic endometrial cancer casesSemantic proximity Read ↗

Frequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients.Semantic proximity Read ↗

Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: associations with family history and histopathology.Semantic proximity Read ↗

MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers.Semantic proximity Read ↗

Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancerSemantic proximity Read ↗

Identification of germline MSH2 gene mutations in endometrial cancer not fulfilling the new clinical criteria for hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.