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Article

Absence of mutations in DNA mismatch repair genes in sporadic endometrial tumors with microsatellite instability.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 1996

Lim P C, Tester D, Cliby W, Ziesmer S C, Roche P C, Hartmann L, Thibodeau S N, Podratz K C, Jenkins R B

Abstract excerpt

DNA mismatch repair genes have been reported to play a role in the pathogenesis of hereditary nonpolyposis colorectal cancer (HNPCC). Mutations of DNA mismatch repair genes have accounted for 90% of HNPCC-related colon and endometrial tumors. These mutations have been associated with microsatellite instability (MIN). Because endometrial cancer (EC) is the most common extracolonic malignancy associated with HNPCC,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9816148

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of mutations in DNA mismatch repair genes in sporadic endometrial tumors with microsatellite instability.PMID 9816148Read ↗

Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.Semantic proximity Read ↗

Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers.Semantic proximity Read ↗

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial CancersSemantic proximity Read ↗

Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma.Semantic proximity Read ↗

Hereditary and somatic DNA mismatch repair gene mutations in sporadic endometrial carcinomaSemantic proximity Read ↗

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.Semantic proximity Read ↗

Usefulness of immunohistochemistry for mismatch repair protein and microsatellite instability examination in adenocarcinoma and background endometrium of sporadic endometrial cancer casesSemantic proximity Read ↗

Frequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients.Semantic proximity Read ↗

Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: associations with family history and histopathology.Semantic proximity Read ↗

MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers.Semantic proximity Read ↗

Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancerSemantic proximity Read ↗

Identification of germline MSH2 gene mutations in endometrial cancer not fulfilling the new clinical criteria for hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

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