Hereditary and somatic DNA mismatch repair gene mutations in sporadic endometrial carcinoma

Abstract excerpt

EDITOR-Endometrial cancer (EC) is the second most common malignancy in the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. In a recent large study, cumulative cancer incidences by the age of 70 in HNPCC mutation carriers were: colorectal 82%, endometrial 60%, gastric 13%, and ovarian 12%. 2 Interestingly, in female mutation carriers the incidence of endometrial cancer (60%) exceeded that of...

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