Article
Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1997
Hakimi J M, Schoenberg M P, Rondinelli R H, Piantadosi S, Barrack E R
Abstract excerpt
The androgen receptor (AR) contains glutamine (CAG) and glycine (GGC) repeats that are each polymorphic in length. We screened clinically localized prostate cancers for somatic mutations in the length of the CAG and GGC repeats in the AR gene and characterized the length of these repeats in the g...
Topics
- Adenocarcinoma
- Alleles
- Androgens
- DNA Mutational Analysis
- DNA, Neoplasm
- Genetic Variation
- Humans
- Lymphatic Metastasis
- Male
- Mutation
- Neoplasms, Hormone-Dependent
- Prostatic Neoplasms
- Receptors, Androgen
- Risk Factors
- Trinucleotide Repeats
- White People