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Tracking the cell cycle origins for escape from topotecan action by breast cancer cells

1 Apr 2003

Abstract excerpt

The anticancer agent topotecan is considered to be S-phase specific. This implies that cancer cells that are not actively replicating DNA could resist the effects of the drug. The cycle specificity of topotecan action was investigated in MCF-7 cells, using time-lapse microscopy to link the initial cell cycle position during acute exposures to topotecan with the antiproliferative consequences for individual cells....

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PMID: 12698201
DOI: 10.1038/sj.bjc.6600889

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