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Article

Evidence for a close association between helix IV and helix XI in the melibiose carrier of Escherichia coli.

Biochimica et biophysica acta - 23 Sept 1998

Hastings Wilson T, Wilson D M

Abstract excerpt

The melibiose carrier of Escherichia coli is a cation-sugar cotransport protein. Asp124 in membrane-spanning helix IV of the carrier protein was replaced with Ser, Ile or Phe by site-directed mutagenesis of a plasmid containing the melB gene. Each of these mutants failed to show membrane transport of melibiose and melibiose-positive revertants could be isolated on melibiose MacConkey indicator plates. D124F...

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Identifiers

PMID: 9814854
DOI: 10.1016/s0005-2736(98)00132-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Evidence for a close association between helix IV and helix XI in the melibiose carrier of Escherichia coli.PMID 9814854Read ↗

Physiological evidence for an interaction between helices II and XI in the melibiose carrier of Escherichia coli.Semantic proximity Read ↗

Physiological evidence for an interaction between helix XI and helices I, II, and V in the melibiose carrier of Escherichia coli.Semantic proximity Read ↗

The melibiose carrier of Escherichia coli: cysteine substitutions for individual residues in helix XI.Semantic proximity Read ↗

Cysteine substitutions for individual residues in helix VI of the melibiose carrier of Escherichia coli.Semantic proximity Read ↗

Sugar recognition mutants of the melibiose carrier of Escherichia coli: possible structural information concerning the arrangement of membrane-bound helices and sugar/cation recognition site.Semantic proximity Read ↗

The proximity between helix I and helix XI in the melibiose carrier of Escherichia coli as determined by cross-linking.Semantic proximity Read ↗

Arg-52 in the melibiose carrier of Escherichia coli is important for cation-coupled sugar transport and participates in an intrahelical salt bridge.Semantic proximity Read ↗

Transport properties of Asp-51-->Glu and Asp-120-->Glu mutants of the melibiose carrier of Escherichia coli.Semantic proximity Read ↗

Resistance of the melibiose carrier to inhibition by the phosphotransferase system due to substitutions of amino acid residues in the carrier of Salmonella typhimurium.Semantic proximity Read ↗

Alteration of Na(+)-coupled transport in site-directed mutants of the melibiose carrier of Escherichia coli.Semantic proximity Read ↗

An investigation of cysteine mutants on the cytoplasmic loop X/XI in the melibiose transporter of Escherichia coli by using thiol reagents: implication of structural conservation of charged residues.Semantic proximity Read ↗

Evidence for a role of helix IV in connecting cation- and sugar-binding sites of Escherichia coli melibiose permease.Semantic proximity Read ↗

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