Resistance of the melibiose carrier to inhibition by the phosphotransferase system due to substitutions of amino acid residues in the carrier of Salmonella typhimurium.

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Article

Resistance of the melibiose carrier to inhibition by the phosphotransferase system due to substitutions of amino acid residues in the carrier of Salmonella typhimurium.

The Journal of biological chemistry - 15 Sept 1992

Kuroda M, de Waard S, Mizushima K, Tsuda M, Postma P, Tsuchiya T

Abstract excerpt

The melibiose carrier of Salmonella typhimurium is under the control of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). We isolated mutants of the melibiose carrier that showed resistance to inhibition via the PTS. Growth of the mutants on melibiose was not inhibited by 2-deoxyglucose, a non-metabolizable substrate of the PTS, although growth of the parent strain was inhibited. Transport...

Topics

Amino Acid Sequence
Amino Acids
Biological Transport
Blotting, Southern
Cloning, Molecular
DNA, Bacterial
Deoxyglucose
Membrane Transport Modulators
Membrane Transport Proteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phosphoenolpyruvate Sugar Phosphotransferase System

Plasmids

Salmonella typhimurium

Sequence Homology, Nucleic Acid

Symporters

Source

Open in PubMed

Identifiers

PMID: 1526973

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1526973-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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