Article
RNase P-associated external guide sequence effectively reduces the expression of human CC-chemokine receptor 5 and inhibits the infection of human immunodeficiency virus 1.
BioMed research international - 1 Jan 2013
Zeng Wenbo, Vu Gia-Phong, Bai Yong, Chen Yuan-Chuan, Trang Phong, Lu Sangwei, Xiao Gengfu, Liu Fenyong
Abstract excerpt
External guide sequences (EGSs) represent a new class of RNA-based gene-targeting agents, consist of a sequence complementary to a target mRNA, and render the target RNA susceptible to degradation by ribonuclease P (RNase P). In this study, EGSs were constructed to target the mRNA encoding human CC-chemokine receptor 5 (CCR5), one of the primary coreceptors for HIV. An EGS RNA, C1, efficiently directed human...
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