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Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA

28 Jun 2005

Abstract excerpt

BACKGROUND: West Nile virus is an emerging human pathogen for which specific antiviral therapy has not been developed. Recent studies have suggested that RNA interference (RNAi) has therapeutic potential as a sequence specific inhibitor of viral infection. Here, we examine the ability of exogenous small interfering RNAs (siRNAs) to block the replication of West Nile virus in human cells. RESULTS: WNV replication...

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PMID: 15985182
DOI: 10.1186/1743-422x-2-53

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