Article
Inefficient recognition of autologous viral sequences by intrahepatic hepatitis C virus-specific cytotoxic T lymphocytes in chronically infected subjects.
Virology - 10 Nov 1998
Giuggio V M, Bonkovsky H L, Smith J, Rothman A L
Abstract excerpt
Cytotoxic T lymphocytes (CTL) capable of recognizing prototype hepatitis C virus (HCV) sequences have been shown to localize to the liver in chronically infected individuals, where they are thought to influence hepatic inflammation and viral replication. We isolated three intrahepatic CD8(+) CTL...
Topics
- Amino Acid Sequence
- Antigens, Viral
- Cell Line
- Cells, Cultured
- Cytotoxicity Tests, Immunologic
- Epitope Mapping
- Epitopes
- Genes, MHC Class I
- Genome, Viral
- Genotype
- Hepacivirus
- Hepatitis C, Chronic
- Humans
- Liver
- Molecular Sequence Data
- RNA, Viral
- T-Lymphocytes, Cytotoxic
- Vaccinia virus