Article
Characterization of a heparin binding site on the heavy chain of factor XI.
The Journal of biological chemistry - 20 Nov 1998
Zhao M, Abdel-Razek T, Sun M F, Gailani D
Abstract excerpt
The glycosaminoglycan heparin enhances several reactions involving coagulation factor XI (FXI) including activation of FXI by factor XIIa, thrombin, and autoactivation; and inactivation of activated FXI (FXIa) by serine protease inhibitors. We examined the effect of heparin on inhibition of FXIa...
Topics
- Alanine
- Amino Acids, Diamino
- Antithrombin III
- Binding Sites
- Chromatography, Affinity
- Complement C1 Inactivator Proteins
- Complement C1 Inhibitor Protein
- Enzyme Activation
- Factor XI
- Factor XIa
- Glutamic Acid
- Heparin
- Mutation
- Recombinant Proteins
- Sepharose