Article
Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency.
Blood - 15 Jun 2003
Salomon Ophira, Zivelin Ariella, Livnat Tami, Dardik Rima, Loewenthal Ron, Avishai Ophelia, Steinberg David M, Rosove Michael H, O'Connell Niamh, Lee Christine A, Seligsohn Uri
Abstract excerpt
Factor XI deficiency, an injury-related bleeding disorder, is rare worldwide but common in Jews in whom 2 mutations, Glu117Stop (type II) and Phe283Leu (type III), prevail. Mean factor XI activities in homozygotes for Glu117Stop and for Phe283Leu are 1 and 10 U/dL, respectively. Inhibitors to factor XI in patients with severe factor XI deficiency have been reported in a small number of instances. This study was...
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