Expression of a foreign epitope on the surface of the adenovirus hexon

Abstract excerpt

To present short protein sequences to the host immune system a foreign epitope has been expressed on the surface of the adenovirus virion as part of the hexon. As the trimeric hexon constitutes 240 out of the 252 capsomers of the virus, the foreign epitope is repeated 720 times on the virion surface. An eight amino acid sequence from the major antigenic site in the VP1 capsid protein of poliovirus type 3 was...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Viral Infections and Immunology Research
• Share to Viral Infectious Diseases and Gene Expression in Insects
• Share to Virus-based gene therapy research