Reduced misreading of asparagine codons by Escherichia coli tRNALys with hypomodified derivatives of 5-methylaminomethyl-2-thiouridine in the wobble position.

doi:10.1006/jmbi.1998.2162

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Article

Reduced misreading of asparagine codons by Escherichia coli tRNALys with hypomodified derivatives of 5-methylaminomethyl-2-thiouridine in the wobble position.

Journal of molecular biology - 20 Nov 1998

Hagervall T G, Pomerantz S C, McCloskey J A

Abstract excerpt

It has been suggested that modified nucleosides of the xm5(s2)U(m)34-type restrict the wobble capacity of the base, and that their function is to prevent misreading in the third position of the codon in mixed codon family boxes that encode two different amino acids. In this study in Escherichia c...

Topics

Asparagine
Capsid
Capsid Proteins
Codon
Escherichia coli
Mutation
Protein Biosynthesis
RNA, Transfer, Lys
RNA-Binding Proteins
Thiouridine

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