Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?

doi:10.1038/sj.onc.1202149

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Article

Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?

Oncogene - 5 Nov 1998

Magnusson K P, Satalino R, Qian W, Klein G, Wiman K G

Abstract excerpt

Most solid tumors are unable to grow in the ascites form, unless selected by prolonged serial transfer of peritoneal fluid (Klein, 1955). Established ascites tumor cells grow under highly crowded, virtually anoxic conditions (Warburg and Hiepler, 1953). Hypoxia was recently identified as a powerf...

Topics

Animals
Ascites
Cell Hypoxia
Gene Deletion
Genes, p53
Mammary Neoplasms, Experimental
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mutation
Neoplasms, Experimental
Sarcoma, Experimental
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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