Article
STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.
Cancer research - 1 Nov 1998
Resta N, Simone C, Mareni C, Montera M, Gentile M, Susca F, Gristina R, Pozzi S, Bertario L, Bufo P, Carlomagno N, Ingrosso M, Rossini F P, Tenconi R, Guanti G
Abstract excerpt
A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analy...
Topics
- AMP-Activated Protein Kinase Kinases
- Colorectal Neoplasms
- Genes, Tumor Suppressor
- Humans
- Loss of Heterozygosity
- Mutation
- Peutz-Jeghers Syndrome
- Protein Serine-Threonine Kinases