Article
Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
Cancer research - 1 Sept 1998
Dong S M, Kim K M, Kim S Y, Shin M S, Na E Y, Lee S H, Park W S, Yoo N J, Jang J J, Yoon C Y, Kim J W, Kim S Y, Yang Y M, Kim S H, Kim C S, Lee J Y
Abstract excerpt
We analyzed somatic mutation and loss of heterozygosity (LOH) in the serine/threonine kinase 11 (STK11)/Peutz-Jeghers syndrome gene in 49 colorectal tumors in three different stages of a dysplasia-carcinoma sequence. We detected LOH in 10 of 19 (52.6%) informative colorectal cancers at loci D19S8...
Topics
- AMP-Activated Protein Kinase Kinases
- Base Sequence
- Chromosomes, Human, Pair 19
- Colonic Neoplasms
- Genes, Tumor Suppressor
- Humans
- Loss of Heterozygosity
- Molecular Sequence Data
- Mutation
- Peutz-Jeghers Syndrome
- Protein Serine-Threonine Kinases