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Article

Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.

Cancer research - 1 Sept 1998

Dong S M, Kim K M, Kim S Y, Shin M S, Na E Y, Lee S H, Park W S, Yoo N J, Jang J J, Yoon C Y, Kim J W, Kim S Y, Yang Y M, Kim S H, Kim C S, Lee J Y

Abstract excerpt

We analyzed somatic mutation and loss of heterozygosity (LOH) in the serine/threonine kinase 11 (STK11)/Peutz-Jeghers syndrome gene in 49 colorectal tumors in three different stages of a dysplasia-carcinoma sequence. We detected LOH in 10 of 19 (52.6%) informative colorectal cancers at loci D19S886 and/or D19S883, but no LOH was observed in 25 informative adenomas. We detected a total of 9 somatic mutations [7 of...

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Identifiers

PMID: 9731485

Genes

STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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