Protein Kinase Profile of Sperm and Eggs: Cloning and Characterization of Two Novel Testis-Specific Protein Kinases (AIE1, AIE2) Related to Yeast and Fly Chromosome Segregation Regulators

Abstract excerpt

We have analyzed the general protein kinase expression profile in mouse sperm and eggs. A total of 41 different kinases were identified. In this study, we describe two novel protein kinases, designated AIE1 (mouse) and AIE2 (human), which share high amino acid identities with the serine/threonine (S/T) kinase domain of yeast Ip11, fly aurora, and frog Eg2. Mutations in Ip11 and aurora have been reported to cause...

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