Article
Effects of extracellular matrix proteins in chondrocyte-derived matrices on chondrocyte functions.
Biotechnology progress - 1 Jan 2000
Hoshiba Takashi, Lu Hongxu, Kawazoe Naoki, Yamada Tomoe, Chen Guoping
Abstract excerpt
Loss of cartilaginous phenotype during in vitro expansion culture of chondrocytes is a major barrier to the application of chondrocytes for tissue engineering. In previous study, we showed that dedifferentiation of chondrocytes during the passage culture was delayed by matrices formed by primary chondrocytes (P0-ECM). In this study, we investigated bovine chondrocyte functions when being cultured on isolated...
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