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Article

The complement regulatory proteins CD46 and CD59, but not CD55, are highly expressed by glandular epithelium of human breast and colorectal tumour tissues

1 Jul 1998

Abstract excerpt

Three of the proteins protecting cells from autologous lysis by complement are: membrane cofactor protein (MCP; CD46), an inhibitor of the membrane attack complex formation (CD59), and decay accelerating factor (DAF; CD55). We have investigated the expression of these proteins in breast and colorectal carcinoma by immunohistochemistry and immunoblotting of breast tissue for CD46. CD46 was consistently and...

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PMID: 9808413
DOI: 10.1111/j.1699-0463.1998.tb00233.x

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Related research

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The complement regulatory proteins CD46 and CD59, but not CD55, are highly expressed by glandular epithelium of human breast and colorectal tumour tissuesPMID 9808413Read ↗

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Expression of the membrane complement regulatory protein CD59 (protectin) is associated with reduced survival in colorectal cancer patientsSemantic proximity Read ↗

Molecular cloning of a murine homologue of membrane cofactor protein (CD46): preferential expression in testicular germ cellsSemantic proximity Read ↗

Three soluble form messages of murine CD46 are produced through alternative mRNA splicing.Semantic proximity Read ↗

Disruption of Mouse CD46 Causes an Accelerated Spontaneous Acrosome Reaction in SpermSemantic proximity Read ↗

CD59a Is the Primary Regulator of Membrane Attack Complex Assembly in the MouseSemantic proximity Read ↗

Identification and characterization of a silencer regulatory element in the 3'-flanking region of the murine CD46 gene.Semantic proximity Read ↗

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