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Disruption of Mouse CD46 Causes an Accelerated Spontaneous Acrosome Reaction in Sperm

15 Mar 2003

Abstract excerpt

Human membrane cofactor protein (MCP, CD46) is a ubiquitously expressed protein known to protect cells from complement attack. Interestingly, when we examined the expression of mouse CD46, which we recently cloned, the message was found only in testis and the protein was found on the inner acrosomal membrane of sperm. In order to elucidate the function of CD46, we produced mice carrying a null mutation in the...

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PMID: 12640142
DOI: 10.1128/mcb.23.7.2614-2622.2003

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