Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age.

Annals of hematology - 1 May 2007

van den Heuvel-Eibrink Marry M, van der Holt Bronno, Burnett Alan K, Knauf Wolfgang U, Fey Martin F, Verhoef Gregor E G, Vellenga Edo, Ossenkoppele Gert J, Löwenberg Bob, Sonneveld Pieter

Abstract excerpt

Clinical resistance to chemotherapy in acute myeloid leukemia (AML) is associated with the expression of the multidrug resistance (MDR) proteins P-glycoprotein, encoded by the MDR1/ABCB1 gene, multidrug resistant-related protein (MRP/ABCC1), the lung resistance-related protein (LRP), or major vault protein (MVP), and the breast cancer resistance protein (BCRP/ABCG2). The clinical value of MDR1, MRP1, LRP/MVP, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Share to ATP-Binding Cassette Transporters

Share to Disease-Free Survival

Share to Leukemia, Myeloid

Share to Multidrug Resistance-Associated Proteins

Share to Neoplasm Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17340137
DOI: 10.1007/s00277-007-0269-7
PMCID: PMC1914243

Genes

MVP
ABCB1
ABCC1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age.PMID 17340137Read ↗

Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study.Semantic proximity Read ↗

Acute Myeloid Leukemia in the Elderly: Assessment of Multidrug Resistance (MDR1) and Cytogenetics Distinguishes Biologic Subgroups With Remarkably Distinct Responses to Standard Chemotherapy. A Southwest Oncology Group StudySemantic proximity Read ↗

P-glycoprotein and multidrug resistance-associated protein-1 expression in acute myeloid leukemia: Biological and prognosis implications.Semantic proximity Read ↗

<i>MDR1</i> and <i>MRP1</i> gene expression are independent predictors for treatment outcome in adult acute myeloid leukaemiaSemantic proximity Read ↗

Prognostic Significance of Multidrug Resistance Gene 1 (MDR1), Multidrug Resistance-related Protein (MRP) and Lung Resistance Protein (LRP) mRNA Expression in Acute LeukemiaSemantic proximity Read ↗

Targeting the multidrug resistance-1 transporter in AML: molecular regulation and therapeutic strategiesSemantic proximity Read ↗

Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patientsSemantic proximity Read ↗

Classical multidrug resistance in acute myeloid leukaemia.Semantic proximity Read ↗

Multidrug resistance in leukemiaSemantic proximity Read ↗

The prognostic significance of membrane transport-associated multidrug resistance (MDR) proteins in leukemiaSemantic proximity Read ↗

Highly refractory acute myeloid leukemia.Semantic proximity Read ↗

Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.