Article
Sterol carrier protein 2 participates in hypersecretion of biliary cholesterol during gallstone formation in genetically gallstone-susceptible mice.
The Biochemical journal - 15 Nov 1998
Fuchs M, Lammert F, Wang D Q, Paigen B, Carey M C, Cohen D E
Abstract excerpt
In inbred mice, susceptibility to cholesterol gallstone disease is conferred by Lith genes, which in part promote hypersecretion of cholesterol into bile in response to a high-fat/cholesterol/cholic acid (lithogenic) diet. Because cytosolic sterol carrier protein 2 (SCP2) is believed to participa...
Topics
- Animals
- Biliary Tract
- Carrier Proteins
- Cholelithiasis
- Cholesterol
- Cholesterol, Dietary
- Cholic Acid
- Dietary Fats
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Phenotype
- Plant Proteins
- RNA, Messenger