Article
Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p.
The Journal of biological chemistry - 21 Nov 1997
Haak D, Gable K, Beeler T, Dunn T
Abstract excerpt
The Saccharomyces cerevisiae SCS7 and SUR2 genes are members of a gene family that encodes enzymes that desaturate or hydroxylate lipids. Sur2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramide, and Scs7p is required for the hydroxylation of the very long chain fatty acid. Neither SCS7 nor SUR2 are essential for growth, and lack of the Scs7p- or Sur2p-dependent hydroxylation does not...
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