Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defects in adhesion and migration, but not in proliferation and differentiation, of embryonic stem cells upon replacement of integrin subunit beta1A by beta1D.

Differentiation; research in biological diversity - 1 Oct 2000

Gimond C, Baudoin C, Sonnenberg A

Abstract excerpt

Beta1D is a skeletal muscle-specific splice variant of the beta1 integrin subunit, while beta1A integrin subunit has a wide tissue distribution. We have previously shown that replacement of beta1A by beta1D by homologous recombination (knockin) in all mouse tissues was embryonic lethal. Through two successive rounds of homologous recombination, we have now produced embryonic stem (ES) cells expressing beta1D...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrin beta1

Share to Muscle, Skeletal

Share to Myocardium

Share to Neurites

Share to Restriction Mapping

Share to Stem Cells

Source

Identifiers

PMID: 11100900
DOI: 10.1046/j.1432-0436.2000.660204.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defects in adhesion and migration, but not in proliferation and differentiation, of embryonic stem cells upon replacement of integrin subunit beta1A by beta1D.PMID 11100900Read ↗

Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development.Semantic proximity Read ↗

Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.Semantic proximity Read ↗

Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells.Semantic proximity Read ↗

A novel β1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscleSemantic proximity Read ↗

A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes.Semantic proximity Read ↗

Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development.Semantic proximity Read ↗

Integrin alpha-5 subunit is critical for the early stages of human pluripotent stem cell cardiac differentiationSemantic proximity Read ↗

Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.Semantic proximity Read ↗

Na,K-ATPase subunit beta1 knock-in prevents lethality of beta2 deficiency in mice.Semantic proximity Read ↗

Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system.Semantic proximity Read ↗

Different Consequences of β1 Integrin Deletion in Neonatal and Adult Mouse Epidermis Reveal a Context-Dependent Role of Integrins in Regulating Proliferation, Differentiation, and Intercellular CommunicationSemantic proximity Read ↗

Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.