Article
Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores.
Genomics - 1 Nov 1998
Wilkinson J, Grimley S, Collins A, Thomas N S, Holgate S T, Morton N
Abstract excerpt
We present evidence of linkage between markers on chromosome 12 and asthma using the BETA program for nonparametric single- and multipoint linkage analysis. We have used quantitative scores as our phenotypic variables, combining data into indices for asthma and atopy and maximizing heritability....
Topics
- Adolescent
- Alleles
- Asthma
- Child
- Chromosomes, Human, Pair 12
- Family
- Female
- Genetic Linkage
- Genetic Markers
- Humans
- Hypersensitivity, Immediate
- Lod Score
- Male
- Phenotype
- Quantitative Trait, Heritable
- Software