Article
Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores.
Genomics - 1 Nov 1998
Wilkinson J, Grimley S, Collins A, Thomas N S, Holgate S T, Morton N
Abstract excerpt
We present evidence of linkage between markers on chromosome 12 and asthma using the BETA program for nonparametric single- and multipoint linkage analysis. We have used quantitative scores as our phenotypic variables, combining data into indices for asthma and atopy and maximizing heritability. The largest single-locus LODs were achieved for asthma: D12S342 and asthma score (LOD 2.255), D12S324 and asthma...
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