Article
Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy.
The Journal of allergy and clinical immunology - 1 Aug 1999
Barnes K C, Freidhoff L R, Nickel R, Chiu Y F, Juo S H, Hizawa N, Naidu R P, Ehrlich E, Duffy D L, Schou C, Levett P N, Marsh D G, Beaty T H
Abstract excerpt
BACKGROUND: Asthma is a complex disease characterized by a high prevalence of allergic diathesis and the almost ubiquitous presence of upper airway disease (eg, rhinitis). Previously, we observed linkage of asthma among Afro-Caribbean families to markers in chromosome 12q, which contains a number of genes encoding for products closely related to allergic airway inflammation and disease. OBJECTIVE: To identify...
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