Article
Linkage analysis of chromosome 12 markers in Italian families with atopic asthmatic children.
American journal of respiratory and critical care medicine - 1 Oct 2000
Malerba G, Lauciello M C, Scherpbier T, Trabetti E, Galavotti R, Cusin V, Pescollderungg L, Zanoni G, Martinati L C, Boner A L, Levitt R C, Pignatti P F
Abstract excerpt
We investigated 116 Italian atopic families (560 individuals) for linkage with 13 DNA markers on chromosome 12. All the subjects were phenotyped for asthma, total serum IgE, bronchial hyperresponsiveness, skin-prick positivity to common aeroallergens, and atopy. A relative location map of the markers was prepared from Centre d'Etude du Polymorphisme Humain families. Affected sib pair multipoint linkage methods...
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