Article
Muscle-specific accumulation of Drosophila myosin heavy chains: a splicing mutation in an alternative exon results in an isoform substitution.
The EMBO journal - 1 Sept 1991
Kronert W A, Edwards K A, Roche E S, Wells L, Bernstein S I
Abstract excerpt
We show that the molecular lesions in two homozygousviable mutants of the Drosophila muscle myosin heavy chain gene affect an alternative exon (exon 9a) which encodes a portion of the myosin head that is highly conserved among both cytoplasmic and muscle myosins of all organisms. In situ hybridiz...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- DNA
- Drosophila melanogaster
- Exons
- Homozygote
- Molecular Sequence Data
- Muscles
- Mutation
- Myosins
- Nucleic Acid Hybridization
- Polymerase Chain Reaction
- RNA Probes
- RNA Splicing