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Article

Transformation of Drosophila melanogaster with the wild-type myosin heavy-chain gene: rescue of mutant phenotypes and analysis of defects caused by overexpression.

The Journal of cell biology - 1 Aug 1994

Cripps R M, Becker K D, Mardahl M, Kronert W A, Hodges D, Bernstein S I

Abstract excerpt

We have transformed Drosophila melanogaster with a genomic construct containing the entire wild-type myosin heavy-chain gene, Mhc, together with approximately 9 kb of flanking DNA on each side. Three independent lines stably express myosin heavy-chain protein (MHC) at approximately wild-type levels. The MHC produced is functional since it rescues the mutant phenotypes of a number of different Mhc alleles: the...

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Identifiers

PMID: 8045933
DOI: 10.1083/jcb.126.3.689
PMCID: PMC2120147

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