Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor.

doi:10.1046/j.1471-4159.1998.71052169.x

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Article

Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor.

Journal of neurochemistry - 1 Nov 1998

Boess F G, Monsma F J, Sleight A J

Abstract excerpt

We have examined the ligand binding site of the serotonin 5-HT6 receptor using site-directed mutagenesis. Replacing the highly conserved Asp106 in transmembrane region III by asparagine eliminated D-[3H]-lysergic acid diethylamide ([3H]LSD) binding to the mutant receptor transiently expressed in...

Topics

Adenylyl Cyclases
Amino Acid Substitution
Binding Sites
Binding, Competitive
Cell Line
Cyclic AMP
Humans
Ligands
Lysergic Acid Diethylamide
Mutagenesis, Site-Directed
Mutation
Receptors, Serotonin
Serotonin
Serotonin Receptor Agonists

Source

Open in PubMed

Identifiers

PMID: 9798944
DOI: 10.1046/j.1471-4159.1998.71052169.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9798944-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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