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Article

Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D.

Biochemistry - 22 Nov 2011

Madan Lalima L, Gopal B

Abstract excerpt

The coordinated activity of protein tyrosine phosphatases (PTPs) is crucial for the initiation, modulation, and termination of diverse cellular processes. The catalytic activity of this protein depends on a nucleophilic cysteine at the active site that mediates the hydrolysis of the incoming phosphotyrosine substrate. While the role of conserved residues in the catalytic mechanism of PTPs has been extensively...

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PMID: 22007620
DOI: 10.1021/bi201092q
PMCID: PMC3667199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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