Article
Analysis of the three-dimensional antigenic structure of giant ragweed allergen, Amb t 5.
Molecular immunology - 1 Jun 1998
Rafnar T, Brummet M E, Bassolino-Klimas D, Metzler W J, Marsh D G
Abstract excerpt
The ragweed allergens Amb t 5 and Amb a 5 are among the smallest inhaled protein allergens known, containing a single, immunodominant T-cell epitope. In this study we analyzed the B-cell epitope structure of Amb t 5. The three-dimensional structures of Amb t 5 and Amb a 5 have been determined by NMR spectroscopy, providing a rare opportunity to analyze three-dimensional antigenic sites. Amb t 5 residues likely to...
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