Article
Interleukin-1beta+3953 allele 2: association with disease status in adult periodontitis.
Journal of clinical periodontology - 1 Oct 1998
Gore E A, Sanders J J, Pandey J P, Palesch Y, Galbraith G M
Abstract excerpt
Adult periodontitis is a complex multifactorial disease whose etiology is not well defined. The pro-inflammatory and bone resorptive properties of interleukin-1 beta (IL-1beta) strongly suggest a role for this cytokine in the pathogenesis of periodontal disease. In the study reported here, the fr...
Topics
- Adult
- Alleles
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin-1
- Linkage Disequilibrium
- Male
- Neutrophil Activation
- Neutrophils
- Odds Ratio
- Periodontitis
- Polymorphism, Restriction Fragment Length
- Statistics, Nonparametric