Article
A functional interleukin-1 beta gene polymorphism is associated with chronic periodontitis in a sample of Brazilian individuals.
Journal of periodontal research - 1 Aug 2005
Moreira Paula R, de Sá Alessandra R, Xavier Guilherme M, Costa José E, Gomez Ricardo S, Gollob Kenneth J, Dutra Walderez O
Abstract excerpt
BACKGROUND: Interleukin-1 beta (IL-1 beta) is a potent inflammatory mediator and an important polymorphism in the locus +3954 (C/T) of the human IL1 B gene has been shown to affect the levels of this cytokine. This functional polymorphism has been associated with the establishment of inflammatory...
Topics
- Adolescent
- Adult
- Aged
- Brazil
- Case-Control Studies
- Cross-Sectional Studies
- Cytosine
- Female
- Gene Frequency
- Humans
- Interleukin-1
- Logistic Models
- Male
- Middle Aged
- Odds Ratio
- Periodontitis
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide