Search for Hepatitis C Virus Extrahepatic Replication Sites in Patients With Acquired Immunodeficiency Syndrome: Specific Detection of Negative–Strand Viral Rna in Various Tissues

Abstract excerpt

The existence of extrahepatic reservoirs of hepatitis C virus (HCV) replication remains highly controversial. We searched for the presence of HCV-RNA negative strand in various tissues from eight HCV-infected patients who died of acquired immunodeficiency syndrome (AIDS)-related complications. Negative-strand RNA was detected by a Tth-based reverse-transcriptase polymerase chain reaction (RT-PCR), which was...

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