Article
Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure.
The American journal of cardiology - 15 Oct 1998
Pfeufer A, Busjahn A, Vergopoulos A, Knoblauch H, Urata H, Osterziel K J, Menz M, Wienker T F, Faulhaber H D, Steinmetz A, Schuster H, Dietz R, Luft F C
Abstract excerpt
The chymase gene is said to be important for the generation of angiotensin II in the heart and therefore is a candidate gene for heart disease. However, we were unable to find an association between allelic variants of the chymase gene and acute myocardial infarction or linkage between the chymas...
Topics
- Adult
- Base Sequence
- Blood Pressure
- Cardiomegaly
- Chymases
- Female
- Genetic Linkage
- Genotype
- Humans
- Male
- Microsatellite Repeats
- Molecular Sequence Data
- Myocardial Infarction
- Polymorphism, Genetic