Cytodifferentiating agents affect the replication of herpes simplex virus type 1 in the absence of functional VP16.

doi:10.1006/viro.1998.9314

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Article

Cytodifferentiating agents affect the replication of herpes simplex virus type 1 in the absence of functional VP16.

Virology - 30 Sept 1998

Preston C M, McFarlane M

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) mutant in1814 encodes an altered form of the virion protein VP16 that is unable to transactivate immediate-early (IE) transcription. As a consequence of the mutation, in1814 initiates productive replication inefficiently after infection of tissue culture ce...

Topics

Acetamides
Animals
Cell Differentiation
DNA Damage
Genes, Immediate-Early
Genes, Viral
Genetic Complementation Test
Herpes Simplex Virus Protein Vmw65
Herpesvirus 1, Human
Hydroxamic Acids
Mice
Mutation
Niacinamide
Promoter Regions, Genetic
Tumor Cells, Cultured
Virus Replication
Vorinostat

Source

Open in PubMed

Identifiers

PMID: 9791032
DOI: 10.1006/viro.1998.9314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9791032-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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