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IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection

14 Apr 2022

Abstract excerpt

Human cytomegalovirus (HCMV) gathers all the substrates and enzymes necessary for the assembly of new virions from its host cell. For instance, HCMV is known to induce cellular metabolism of infected cells to favor virion assembly. Cells are, however, equipped with a first-line defense represented by restriction factors (RFs), which after sensing viral DNA can trigger innate and adaptive responses, thereby...

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PMID: 35420480
DOI: 10.1128/mbio.00435-22

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