Hexamethylene bisacetamide stimulates herpes simplex virus immediate early gene expression in the absence of trans-induction by Vmw65.

doi:10.1099/0022-1317-73-2-285

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Article

Hexamethylene bisacetamide stimulates herpes simplex virus immediate early gene expression in the absence of trans-induction by Vmw65.

The Journal of general virology - 1 Feb 1992

McFarlane M, Daksis J I, Preston C M

Abstract excerpt

Hexamethylene bisacetamide (HMBA) and DMSO are known to induce differentiation of cultured erythroleukaemic cells and to enhance the reactivation of latent herpes simplex virus (HSV) after explantation of ganglia. We report that the presence of these compounds in cell culture medium overcomes the replication defect of in1814, an HSV-1 mutant with an insertion mutation that inactivates the virion trans-inducing...

Topics

Acetamides
Animals
Azacitidine
Base Sequence
Cell Line
DNA, Viral
Dimethyl Sulfoxide
Gene Expression Regulation, Viral
HeLa Cells
Hematinics
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypoxanthine

Hypoxanthines

Immediate-Early Proteins

Molecular Sequence Data

Mutation

RNA, Viral

Simplexvirus

Source

Open in PubMed

Identifiers

PMID: 1371540
DOI: 10.1099/0022-1317-73-2-285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1371540-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Hexamethylene bisacetamide stimulates herpes simplex virus immediate early gene expression in the absence of trans-induction by Vmw65.PMID 1371540Read ↗

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