Article
Unfavorable pathological characteristics in familial colorectal cancer with low-level microsatellite instability.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2006
Kets Carolien M, Hoogerbrugge Nicoline, Bodmer Danielle, Willems Riki, Brunner Han G, van Krieken Joannes H J M, Ligtenberg Marjolijn J L
Abstract excerpt
A high degree of microsatellite instability (MSI) in colorectal cancer (CRC) is a hallmark of hereditary non-polyposis colorectal cancer (HNPCC), caused by germline defects in the mismatch repair (MMR) genes. A low degree of instability (less than 30% of the microsatellites) is seen in a subset of tumors. To clarify the significance of this low degree of MSI phenotype, we studied the differences between patients...
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