Article
Smooth muscle cell differentiation in vitro: models and underlying molecular mechanisms.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2011
Xie Changqing, Ritchie Raquel P, Huang Huarong, Zhang Jifeng, Chen Y Eugene
Abstract excerpt
Development of in vitro models by which to study smooth muscle cell (SMC) differentiation has been hindered by some peculiarities intrinsic to these cells, namely their different embryological origins and their ability to undergo phenotypic modulation in cell culture. Although many in vitro models are available for studying SMC differentiation, careful consideration should be taken so that the model chosen fits...
Topics
- Animals
- Cell Culture Techniques
- Cell Differentiation
- Embryonic Stem Cells
- Gene Expression Regulation, Developmental
- Humans
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle
- Phenotype
- Signal Transduction