The soluble type 2 insulin-like growth factor (IGF-II) receptor reduces organ size by IGF-II-mediated and IGF-II-independent mechanisms.

doi:10.1074/jbc.273.44.28610

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Article

The soluble type 2 insulin-like growth factor (IGF-II) receptor reduces organ size by IGF-II-mediated and IGF-II-independent mechanisms.

The Journal of biological chemistry - 30 Oct 1998

Zaina S, Squire S

Abstract excerpt

The soluble type 2 insulin-like growth factor (IGF) receptor or IGF-II/mannose 6-phosphate receptor (sIGF2R) is produced in vivo by proteolytic deletion of the transmembrane and intracellular domains of the cellular form of the receptor (IGF2R). There is evidence that sIGF2R is a negative regulat...

Topics

Animals
Base Sequence
Crosses, Genetic
DNA Primers
Heterozygote
Insulin-Like Growth Factor II
Mice
Mice, Transgenic
Organ Size
Phenotype
Receptors, Somatomedin

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