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Article

Identification and synthesis of a major conserved antigenic epitope of Trypanosoma cruzi.

15 Feb 1992

Abstract excerpt

A gene sequence encoding an immunodominant protein with a repetitive epitope from the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, was cloned and expressed. The identified 10-amino acid repeat is present within a high-molecular-weight trypomastigote antigen that appears specific to and conserved among T. cruzi isolates. More importantly, greater than 95% of T. cruzi infection sera,...

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Identifiers

PMID: 1371355
DOI: 10.1073/pnas.89.4.1239

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