A complete protein truncation test for BRCA1 and BRCA2.

doi:10.1038/sj.ejhg.5200172

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Article

A complete protein truncation test for BRCA1 and BRCA2.

European journal of human genetics : EJHG - 1 Jan 2000

Garvin A M

Abstract excerpt

The protein truncation test (PTT) is currently the fastest method in general use for detecting previously unidentified mutations in tumor suppressor genes. Greater than three kilobases of coding sequence can be screened by one PCR reaction, one coupled in vitro transcription/translation reaction,...

Topics

Artifacts
BRCA1 Protein
BRCA2 Protein
Base Sequence
Cell Line
Cycloheximide
DNA Primers
DNA, Complementary
Humans
Mutation
Neoplasm Proteins
Polymerase Chain Reaction
RNA, Messenger
Transcription Factors

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