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Article

An ELISA-based high throughput protein truncation test for inherited breast cancer.

Breast cancer research : BCR - 1 Jan 2010

Lim Mark J, Foster Gabriel J, Gite Sadanand, Ostendorff Heather P, Narod Steven, Rothschild Kenneth J

Abstract excerpt

INTRODUCTION: Breast cancer is the most diagnosed and second leading cause of cancer deaths in the U.S. female population. An estimated 5 to 10 percent of all breast cancers are inherited, caused by mutations in the breast cancer susceptibility genes (BRCA1/2). As many as 90% of all mutations are nonsense mutations, causing a truncated polypeptide product. A popular and low cost method of mutation detection has...

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Identifiers

PMID: 20920338
DOI: 10.1186/bcr2722
PMCID: PMC3096971

Genes

BRCA1
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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