Article
Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations.
Human mutation - 1 Jul 2002
Andrulis Irene L, Anton-Culver Hoda, Beck Jeanne, Bove Betsy, Boyd Jeff, Buys Saundra, Godwin Andrew K, Hopper John L, Li Frederick, Neuhausen Susan L, Ozcelik Hilmi, Peel David, Santella Regina M, Southey Melissa C, van Orsouw Nathalie J, Venter Deon J, Vijg Jan, Whittemore Alice S
Abstract excerpt
A number of methods are used for mutational analysis of BRCA1, a large multi-exon gene. A comparison was made of five methods to detect mutations generating premature stop codons that are predicted to result in synthesis of a truncated protein in BRCA1. These included four DNA-based methods: two-dimensional gene scanning (TDGS), denaturing high performance liquid chromatography (DHPLC), enzymatic mutation...
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