Article
Comparisons of the ability of human IgG3 hinge mutants, IgM, IgE, and IgA2, to form small immune complexes: a role for flexibility and geometry.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1998
Roux K H, Strelets L, Brekke O H, Sandlie I, Michaelsen T E
Abstract excerpt
Various native and hinge-modified forms of Ig with identical Ids were reacted with an anti-Id mAb, and the resultant immune complexes were analyzed by negative stain immunoelectron microscopy. Complexes were scored for their geometry (linear versus ring complexes) and size (dimer, trimer, etc.)....
Topics
- Amino Acid Sequence
- Antigen-Antibody Complex
- Humans
- Immunoglobulin A
- Immunoglobulin E
- Immunoglobulin G
- Immunoglobulin M
- Microscopy, Immunoelectron
- Molecular Sequence Data
- Mutation
- Structure-Activity Relationship