A procedure for detecting selection in highly variable viral genomes: evidence of positive selection in antigenic regions of capsid protein VP1 of foot-and-mouth disease virus.

doi:10.1016/s0166-0934(98)00088-3

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Article

A procedure for detecting selection in highly variable viral genomes: evidence of positive selection in antigenic regions of capsid protein VP1 of foot-and-mouth disease virus.

Journal of virological methods - 1 Oct 1998

Martín M J, Núñez J I, Sobrino F, Dopazo J

Abstract excerpt

A new procedure is described for the detection of positive selection among sequences of viral proteins from highly variable viruses. The approach is based on the estimation of the rates of nonsynonymous to synonymous (ns/s) mutations to the overall genetic distances amongst the sequences compared...

Topics

Antigenic Variation
Antigens, Viral
Aphthovirus
Base Sequence
Capsid
Capsid Proteins
Evolution, Molecular
Mutation
Phylogeny
Selection, Genetic
Serotyping

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